For research abstracts on Mold and food click here.
Br Poult Sci. 2016 Apr;57(2):235-45. doi: 10.1080/00071668.2015.1129664.
Protective effects of Urtica dioica seed extract in aflatoxicosis: histopathological and biochemical findings.
Uyar A1, Yener Z1, Dogan A2.
The ameliorative potential and antioxidant capacity of an extract of Urtica dioica seeds (UDS) was investigated using histopathological changes in liver and kidney, measuring serum marker enzymes, antioxidant defence systems and lipid peroxidation (malondialdehyde (MDA)) content in various tissues of broilers exposed to aflatoxin (AF). A total of 32 broilers were divided randomly into 4 groups: control, UDS extract-treated, AF-treated and AF+UDS extract-treated. Broilers in control and UDS extract-treated groups were fed on a diet without AF. The AF-treated group and AF+UDS extract-treated groups were treated with an estimated 1 mg total AF/kg feed. The AF+UDS extract groups received in addition 30 ml UDS extract/kg diet for 21 d. The AF-treated group had significantly decreased body weight gain when compared to the other groups. Biochemical analysis showed a small increase in the concentrations of serum aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase and lactate dehydrogenase in the AF-treated group compared to that of the control group, whereas concentrations of these enzymes were decreased in the AF+UDS group compared to that of the AF-treated group. Administration of supplementary UDS extract helped restore the AF-induced increase in MDA and reduced the antioxidant system towards normality, particularly in the liver, brain, kidney and heart. Hepatorenal protection by UDS extracts was further supported by the almost normal histology in AF+UDS extract-treated group as compared to the degenerative changes in the AF-treated broilers. It was concluded that UDS extract has a protective hepatorenal effect in broilers affected by aflatoxicosis, probably acting by promoting the antioxidative defence systems.
PMID: 26947348 DOI: 10.1080/00071668.2015.1129664
[PubMed - indexed for MEDLINE]
Green Tea research related to mycotoxin removal/mold illness.
A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins.
ScientificWorldJournal. 2013 Apr 18;2013:767482. doi: 10.1155/2013/767482. Print 2013. Review.
PMID: 23710148 [PubMed - indexed for MEDLINE] Free PMC Article
Toxins (Basel). 2013 Apr 11;5(4):605-17. doi: 10.3390/toxins5040605.
Detection of mycotoxins in patients with chronic fatigue syndrome.
Brewer JH1, Thrasher JD, Straus DC, Madison RA, Hooper D.
Over the past 20 years, exposure to mycotoxin producing mold has been recognized as a significant health risk. Scientific literature has demonstrated mycotoxins as possible causes of human disease in water-damaged buildings (WDB). This study was conducted to determine if selected mycotoxins could be identified in human urine from patients suffering from chronic fatigue syndrome (CFS). Patients (n = 112) with a prior diagnosis of CFS were evaluated for mold exposure and the presence of mycotoxins in their urine. Urine was tested for aflatoxins (AT), ochratoxin A (OTA) and macrocyclic trichothecenes (MT) using Enzyme Linked Immunosorbent Assays (ELISA). Urine specimens from 104 of 112 patients (93%) were positive for at least one mycotoxin (one in the equivocal range). Almost 30% of the cases had more than one mycotoxin present. OTA was the most prevalent mycotoxin detected (83%) with MT as the next most common (44%). Exposure histories indicated current and/or past exposure to WDB in over 90% of cases. Environmental testing was performed in the WDB from a subset of these patients. This testing revealed the presence of potentially mycotoxin producing mold species and mycotoxins in the environment of the WDB. Prior testing in a healthy control population with no history of exposure to a WDB or moldy environment (n = 55) by the same laboratory, utilizing the same methods, revealed no positive cases at the limits of detection.
PMID: 23580077 [PubMed - indexed for MEDLINE] PMCID: PMC3705282 Free PMC Article
Occup Environ Med. 2014 Jun;71 Suppl 1:A63. doi: 10.1136/oemed-2014-102362.197.
0041 Associations of thermophilic actinomycetes and non-tuberculous mycobacteria with respiratory health in occupants of a water-damaged office building.
Park JH1, Cox-Ganser J1, White S1, Laney S1, Caulfield S2, Turner W2, Sumner A3, Kreiss K1. http://www.ncbi.nlm.nih.gov/pubmed/25018429
Toxins (Basel). 2013 Dec 24;6(1):66-80. doi: 10.3390/toxins6010066.
Chronic illness associated with mold and mycotoxins: is naso-sinus fungal biofilm the culprit?
Brewer JH1, Thrasher JD, Hooper D.
It has recently been demonstrated that patients who develop chronic illness after prior exposure to water damaged buildings (WDB) and mold have the presence of mycotoxins, which can be detected in the urine. We hypothesized that the mold may be harbored internally and continue to release and/or produce mycotoxins which contribute to ongoing chronic illness. The sinuses are the most likely candidate as a site for the internal mold and mycotoxin production. In this paper, we review the literature supporting this concept.
PMID: 24368325 [PubMed - indexed for MEDLINE] PMCID: PMC3920250 Free PMC Article
J Autoimmun. 2013 Dec;47:1-16. doi: 10.1016/j.jaut.2013.10.004. Epub 2013 Nov 13.
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects.
Perricone C1, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y.
In 2011 a new syndrome termed 'ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants' was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other adjuvants, as well as infectious components, that also may have an adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with post-vaccination phenomena and macrophagic myofasciitis syndrome. Several mechanisms have been hypothesized to be involved in the onset of adjuvant-induced autoimmunity; a genetic favorable background plays a key role in the appearance on such vaccine-related diseases and also justifies the rarity of these phenomena. This paper will focus on protean facets which are part of ASIA, focusing on the roles and mechanisms of action of different adjuvants which lead to the autoimmune/inflammatory response. The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the initiation of breach of tolerance.
Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:Adjuvant; Autoantibodies; Autoimmune/Inflammatory syndrome induced by adjuvants; Autoimmunity; Saccharomyces cerevisiae; Vaccine
Am J Ind Med. 2013 May;56(5):522-30. doi: 10.1002/ajim.22165. Epub 2013 Feb 6.
Markers of upper airway inflammation associated with microbial exposure and symptoms in occupants of a water-damaged building.
Akpinar-Elci M1, White SK, Siegel PD, Park JH, Visotcky A, Kreiss K, Cox-Ganser JM.
Water damage in buildings has been associated with reports of upper airway inflammation among occupants.
This survey included a questionnaire, allergen skin testing, nasal nitric oxide, and nasal lavage on 153 participants. We conducted exposure assessments of 297 workstations and analyzed collected dust for fungi, endotoxin, and (1 → 3)-β-D-glucan to create floor-specific averages.
Males had higher levels of nasal inflammatory markers, and females reported more symptoms. ECP, IL-8, and MPO were significantly associated with nasal symptoms, flu-like achiness, or chills. Fungi and glucan were positively associated with blowing out thick mucus. Endotoxin was significantly associated with ECP in overall models, and with ECP, IL-8, MPO, and neutrophils among non-atopic females.
In this study, we documented an association between endotoxin and nasal inflammatory markers among office workers. The results of our study suggest that a non-allergic response may contribute to symptoms occurring among occupants in this water-damaged building.
Copyright © 2013 Wiley Periodicals, Inc.
PMID: 23390064 DOI: 10.1002/ajim.22165
[PubMed - indexed for MEDLINE]
For research abstarcts on Mold and food click here.
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